Monday, June 3, 2013

An altered gut microbiota can predict diabetes

June 3, 2013 ? Intestinal bacteria may have a greater influence on us than was previously thought. In a study published in the journal Nature on 29 May, researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden and Chalmers University of Technology, Sweden, show that patients with type 2 diabetes have an altered gut microbiota. Their findings have led to a new model to identify patients at increased risk of developing diabetes.

The human body contains ten times more bacteria than human cells. Most of these bacteria comprise the normal gut microbiota. Our bodies thus contain a vast number of bacterial genes in addition to the genes in our own cells, and are collectively known as the metagenome.

Three Swedish, Gothenburg-based research groups led by Fredrik B?ckhed and Bj?rn Fagergberg, Sahlgrenska Academy, University of Gothenburg, and Jens Nielsen of Chalmers University of Technology compared the metagenome of 145 women with diabetes, impaired glucose tolerance and healthy controls, and showed that women with type 2 diabetes have an altered gut microbiota.

Furthermore, healthy women have higher numbers of gut bacteria known to be producers of butyrate, a fatty acid that has previously been linked to beneficial health effect.

On the basis of these findings, the researchers developed a new model that can distinguish between patients with type 2 diabetes and healthy women by analysis of the metagenome. This model has better predictive value than the classical predictive markers used today, such as body-mass index and waist-hip ratio.

"By examining the patient's gut microbiota, we could predict which patients are at risk of developing diabetes. The big challenge is to find out whether the composition of the gut microbiota promotes the onset of age-related diabetes. If this is the case, this would indicate new opportunities to prevent the disease," says Professor Fredrik B?ckhed.

"In this study, we have developed new methods to analyze the metagenomic data and have been able to exploit much more of the 'unknown' metagenome, that is, the bacteria that have not been previously mapped," continues Jens Nielsen, Professor of Systems Biology at Chalmers University of Technology. "The study is an excellent example of how novel technologies, developed in connection with Chalmers' initiative in life science, can assist in analyzing large amounts of data from the clinic."

The study Gut metagenome in European women with normal, impaired and diabetic glucose control was published in Nature on May 29.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/-D_RaExwA1s/130603092328.htm

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CA-NEWS Summary

Five killed in Oklahoma tornadoes, storms move northeast

OKLAHOMA CITY (Reuters) - Tornadoes killed five people in central Oklahoma including a mother and her baby and menaced Oklahoma City and its hard-hit suburb of Moore, before the storm system tracked northeast early on Saturday. The National Weather Service said the severe weather threat would shift into neighboring Illinois and Missouri, where Governor Jay Nixon declared a state of emergency on Friday.

Turkish PM calls for immediate end to protests as clashes flare

ISTANBUL/ANKARA (Reuters) - Turkish Prime Minister Tayyip Erdogan called for an immediate end on Saturday to the fiercest anti-government demonstrations for years, as thousands of protesters clashed with riot police in Istanbul and Ankara for a second day. The unrest was triggered by government plans for a replica Ottoman-era barracks housing shops or apartments in Istanbul's Taksim Square, long a venue for political protest, but has widened into a broader show of defiance against Erdogan and his Islamist-rooted Justice and Development Party (AKP).

Fighting in Syria's Qusair; U.N. says world watching

BEIRUT (Reuters) - Syrian troops and Hezbollah guerrillas besieging the border town of Qusair fought with rebels on Saturday as the United Nations warned all sides they could be held accountable for the suffering of civilians trapped there. The Britain-based Syrian Observatory for Human Rights said fighting was taking place inside Qusair and in villages around it, largely controlled by President Bashar al-Assad's forces who have cut off access to the town.

More than 1,000 killed in Iraq violence in May

BAGHDAD (Reuters) - More than 1,000 people were killed in violence in Iraq in May, making it the deadliest month since the sectarian slaughter of 2006-07, the United Nations reported on Saturday, stoking fears of a return to civil war. Nearly 2,000 people have been killed in the last two months as al Qaeda and Sunni Islamist insurgents, invigorated by the Sunni-led revolt in Syria and by Sunni discontent at home, seek to revive the kind of all-out inter-communal conflict that killed tens of thousands five years ago.

Rock guitarist May leads London march against badger cull

LONDON (Reuters) - Protesters dressed as badgers and led by Queen guitarist Brian May marched through central London on Saturday demanding that the government scrap a plan to cull badgers, aimed at slowing the spread of a cattle disease. About 5,000 of the nocturnal black-and-white animals are due to be shot by marksmen in the six-week pilot cull, authorized to begin on Saturday in two areas in southwestern England.

U.S. rebalance to Asia-Pacific gaining steam, Pentagon chief says

SINGAPORE (Reuters) - The U.S. military will devote more air power, ground troops and high-tech weaponry to the Asia-Pacific region as it moves ahead with a strategic rebalance, the U.S. defense chief said on Saturday in a speech that accused China of cyber incursions. In remarks laying out his vision for regional security, Defense Secretary Chuck Hagel assured allies and partners at the annual Shangri-La Security Dialogue in Singapore that the United States was fully able to continue its strategic pivot to the region despite budget constraints at home.

Russia to send nuclear submarines to southern seas

MOSCOW (Reuters) - Russia plans to resume nuclear submarine patrols in the southern seas after a hiatus of more than 20 years following the break-up of the Soviet Union, Itar-Tass news agency reported on Saturday, in another example of efforts to revive Moscow's military. The plan to send Borei-class submarines, designed to carry 16 long-range nuclear missiles, to the southern hemisphere follows President Vladimir Putin's decision in March to deploy a naval unit in the Mediterranean Sea on a permanent basis starting this year.

Two drone strikes kill seven in southern Yemen: local official

ADEN (Reuters) - Two drone strikes killed seven suspected al Qaeda militants in southern Yemen on Saturday morning, a local official said, nine days after U.S. President Barack Obama said he would only use such strikes when a threat was "continuing and imminent". Washington views al Qaeda in the Arabian Peninsula (AQAP) as the movement's most dangerous wing after it attempted to launch bomb attacks on international airliners.

Rajoy sees hope for Spain in jobless figures

MADRID (Reuters) - Jobless figures to be released next week in Spain will be encouraging and the recession-hit country has started to turn a corner, Prime Minister Mariano Rajoy said on Saturday. "I'm not counting chickens here, however I recommend that you pay attention to unemployment and social security numbers on Tuesday the 4th ... If the patterns we've seen are confirmed they will be clearly encouraging," Rajoy said at an economic conference.

Cyprus rescinds citizenship of Assad billionaire cousin

NICOSIA (Reuters) - Cyprus has rescinded citizenship briefly bestowed upon a Syrian billionaire suspected by the European Union of helping to bankroll President Bashar al-Assad's government, authorities said on Saturday. Rami Makhlouf, who is a maternal cousin of Assad, is widely considered part of the Syrian president's inner circle and one of the most influential men in Syria.

Source: http://news.yahoo.com/ca-news-summary-000647171.html

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Sunday, June 2, 2013

Schumer: Immigration bill to pass Senate by July 4

(AP) ? A senator guiding an immigration overhaul bill through Congress says he wants the Senate to pass the measure by July 4 and predicts as many as 70 votes in support.

Democratic Sen. Chuck Schumer said Sunday that the bipartisan coalition of lawmakers working on the bill is moving forward over House Republicans' objections. The New York senator adds that the eight lawmakers who developed the legislation would consider amendments to their proposal.

Schumer says that if Republicans oppose an overhaul of immigration laws, they will see their party relegated to minority status for a generation. He predicts voters will punish lawmakers who stand in the way of an overhaul and says House Speaker John Boehner is in a tough spot with conservatives.

Schumer spoke to NBC's "Meet the Press."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-06-02-US-Immigration/id-77d08837263e4039a6ebe4bfbf69caac

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Hepatitis A outbreak linked to Ore. berry farm

WASHINGTON (AP) ? The Food and Drug Administration is investigating an outbreak of hepatitis A linked to a frozen organic berry mix from a farm in Oregon.

The FDA and the federal Centers for Disease Control and Prevention said Friday that 30 illnesses are linked to Townsend Farms Organic Anti-Oxidant Blend, which contains pomegranate seed mix. Illnesses were reported in Colorado, New Mexico, Nevada, Arizona and California.

Hepatitis A is a contagious liver disease that can last from a few weeks to a several months. It is spread when a person ingests, even in tiny amounts, contaminated fecal matter.

The FDA said it is inspecting the processing facilities of Townsend Farms of Fairview, Ore., which sold the mix.

Hepatitis A illnesses occur within 15 to 50 days of exposure to the virus. Symptoms include fatigue, abdominal pain, jaundice, abnormal liver tests, dark urine and pale stool.

Vaccination can prevent illness if given within two weeks of exposure, and those who have already been vaccinated are unlikely to become ill, according to CDC.

A lawyer for Townsend Farms has not returned calls for comment. The government has not announced a recall, but the CDC recommended that retailers and other food service operators should not sell or serve Townsend Farms Organic Anti-Oxidant Blend.

___

Follow Mary Clare Jalonick on Twitter at http://twitter.com/mcjalonick

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-05-31-Hepatitis%20A%20Outbreak/id-d25a1744f7e141ca89a865dfb67818d8

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So Who is the Dumb Money Ruining the Rental Housing Market ...

The head of Carrington, which is known as an established distressed debt investor, a servicer that has been a target of litigation, and more recently, an early entrant in the single family home rental business, said this week it was no longer buying houses for lease because dumb money had ruined the market. From Bloomberg:

?We just don?t see the returns there that are adequate to incentivize us to continue to invest,? Rose, 55, chief executive officer of Carrington Holding Co. LLC, said in an interview at his Aliso Viejo, California office. ?There?s a lot of ? bluntly ? stupid money that jumped into the trade without any infrastructure, without any real capabilities and a kind of build-it-as-you-go mentality that we think is somewhat irresponsible.?

The degree to which the housing ?recovery? has been driven by speculators isn?t fully appreciated. Reuters tried to pin down a number, but they apparently did it by identifying specific private equity firms and tying them to purchases. They came up with ?at least 10%? in Las Vegas, suggesting that was representative for the most distressed markets.

But while it?s hard to get good data in such a fragmented field, that estimate is likely to be markedly too low. Some sources have said that cash buyers have accounted for as much as 50% of the activity in the hottest states, and those would also have a bigger impact in the national estimates of home price appreciation.

Why are these investors so hard to identify? Many are newbies. One colleague reports that he knows roughly 15 newly minted real estate mini-moguls. They might have had some cash from a previous life on Wall Street, and raised a bit more initial dough from well-heeled friends. But most after buying a few houses then raised money overseas, mainly from the Middle East and China. They may call themselves hedge funds as a way of glamorizing their strategy and justifying asking for hedgie-type fee structures, but it?s more accurate to simply call them investors.

A tally by lawyer and foreclosure fraud investigator Lynn Szymoniak illustrates how the players in her backyard, Palm Beach County, are mainly buyers you?ve never heard of, as opposed to the big PE firms, but upon further digging, a different picture emerges. Her comment via e-mail:

I?ve been researching who is buying up properties from Fannie, Freddie, HUD and the big trustee banks.

You can do this easily enough by searching Deeds filed in 2013, by county.

The systems will provide an alpha list of purchasers from any single seller.

Once you get the name of the purchasers, such as 2012-C Property Holdings, Badger Investments, or THR Florida, LP, then the trick is to find the parent. Many roads seem to lead to Minnetonka, MN.

I like reading the credentials of the management ? such as the top officers of Two Harbors Investment Company, a company favored by Deutsche Bank. Interesting to see that experience with a failed mortgage company is touted like a victory of some strange kind.

After you find the names of the most frequent buyers, you can search deeds by that name to see how many properties were acquired by that company by county in the past 18 months.

Two Harbors is buying many Deutsche Bank foreclosed homes through its subsidiary, THR Florida, LP, after Deutsche Bank loaned Two Harbors $600 million in October 2012.

Interesting, too, to compare the sales price to the value of the mortgage on the trust records.

None of this bodes well for any real housing recovery.

The banks are indeed selling a small portion of their stockpile, and these are some of the buyers
in Palm Beach County so far in 2013:

Break Point Verde, LLC (3)
Cani Vida Corp. (2)
Dalipa, LLC
Danelia, LLC
Delle Alpi, Corp. (3)
Emerald White York, LLC
Expedits, LLC
Fast Holding I, LLC (2)
Grenoble G & F, LLC
Guamavel, LLC
Javelin Holdings, LLC (2)
Just Makers, LLC
Mafal Corp.
Mapag, LLC
Marsh Harbor Investments, LLC (3)
National Nine, LLC
Shiu, LLC
Sociedad Familiar, LLC
St. Andrews Venture, LLC (2)
Tinfloor
Viento Sur Corp.
View Holdings, LLC
AHE Enterprises, Inc.
AIC, LLC
Altun Real Estate LLC
America On Land, LLC
Beckmann, LLC (2)
Bentley Capital Partners, LLC
BMAN Enterprises, LLC
Cabrera Construction, Inc.
Carmenohio Properties, LLC
Clever House, LLC
Come Home, LLC
EDG 302, LLC
EH Pooled Investments, LP
El Torreon, LLC
First Heritage Holdings, LLC
Florida Rental Specialists, LLC
FTC Group, LLC
GHI Capital, LLC
Golden Arrow Management, LLC
Golden Goose Properties, Inc.
GQ Holdings 1329 LLC
Harvest Residential II, LLC
Honey Dew Cleaning, LLC
Juto Rentals 1, LLC
Kamis Properties, LLC
KG Investments Group, LLC
Letana Delray, LLC
M Y N Investments LLC
Maju Enterprises, LLC
Max Simon Properties, LLC
Palm Beach Financial Solutions, LLC (8)
Park Manor Capital Partners, LLC
Portico Properties, LLC
Pure Properties, LLC
RBD Lending Financial, Inc.
Rebound Residential, LLC
Reliable Housing Management, LLC
Seaward T & X, LLC
Spark Propetries, LLC
Stellar Alon, LLC
Strategic Investor Group, LLC
THR Florida LP (2)
Top Red Business LTD
Tundra Realty, LLC
Via Carbonara, LLC
Walnut Street Capital, LLC
WSC Trust LLC
Zakai, LLC
815 7th Street, LLC

To clarify matters, Minnetonka is the home of Pine River, a hedge fund that also owns a REIT, and I?m told the REIT is likely the buyer of the homes. But REITs are required to pay out most of their cash flow as dividends, which limits how much they can spend on maintaining properties. That means that if the REIT is indeed the buyer, Pine River is probably fixing up the homes before flipping them to the REIT. An awful lot less than arms-length pricing, needless to say.

An additional issue is that if Pine River is indeed buying homes all over Florida, as opposed, say, to concentrating in a few markets, that?s also contrary to what most PE investors consider to be a viable strategy. In the discussions I?ve attended, they stressed that there was a dead zone between four houses and about 200, that you can get economies of scale over that level. And if you are managing 200 or more, they need to be in clumped geographically, say a large grouping on the north side of Atlanta and another on one area of another MSA.

Now I?d anticipate, given the keen interest in Florida, that Szymoniak?s list includes some of the real estate mogul wannabes that my colleague discussed. Given all the press about rentals, most observers would assume that they were playing that game too. But my source with the 15 newbie investors said that was often not the case. He said even with other people?s money in the form of foreign investors, they were also leveraging, just not in the form of a mortgage. Berkshire Hathaway, for instance, is providing warehouse lines, marketing them to people who are over the friends and family level of investing but below $25 million. They are expected to repay in 18 to 24 months.

And what are these investors doing? According to my source, they often aren?t renting but are warehousing the properties, sometimes renovating them (I didn?t nail down whether to flip to a renter or to sell to a buyer) or simply holding them for expected appreciation.

So consider what this means. An unknown but in certain locations, meaningful proportion of homes sold are being warehoused yet again, and will be dribbled out later. This means we have not only servicers keeping homes off the market to keep from depressing prices, but certain investors also contributing to the the perception that inventories are tight by keeping homes unoccupied and off the market.

And this strategy is not looking like it will necessarily be a winner. The Bloomberg article reports, as we predicted, that the very act of putting more rental homes on the market has lowered rental rates. And rents are falling before PE investors are showing a profit. Now they may argue that they will, but at this point, it?s what the Japanese call ?seller talk?. The big PE rental empire builders have yet to reach ?stabilized yields? where they?ve got their portfolios leased up and can say based on experience what typical vacancy costs and maintenance costs are. From the story:

Even as demand for rentals rises amid a falling homeownership rate, yields are declining and companies formed to buy the homes that have gone public haven?t yet been profitable?

Funds are buying property now, including homes sold by Carrington, for rents that yield 6 percent to 8 percent a year, before costs such as insurance, taxes and vacancies, according to Rose. Carrington?s model called for mid-single digit net returns on annual rents on an unlevered basis, according to Rose. While returns would vary by market, they would generally be in the mid- to high teens over the duration of the holding period, with the profit from home price appreciation.

This chart from Michael Lombardi, via Testosterone Pit, shows how rent levels are softening:

Screen shot 2013-05-31 at 5.18.13 AM

Mind you, last October, I had institutional investors telling me PE funds who were pitching them were forecasting 5% per annum rental increases. That looked ridiculous to them given stagnant wage growth.

The Bloomberg account makes clear that one of the true believers is PE kahuna Blackstone:

Blackstone Group LP, the largest investor in single-family rentals, has spent $4.5 billion to amass more than 26,000 homes and continues to buy, according to Eric Elder, a spokesman for Invitation Homes, the rental housing division of the world?s largest private equity firm.

?We?re continuing to purchase homes where they fit into our business plan,? Elder said.

Blackstone?s net yields on its occupied houses are about 6 percent to 6.5 percent, Jonathan Gray, the firm?s global head of real estate, said during a May 3 conference call with investors. That?s before using leverage from a $2.1 billion line of credit the private-equity giant arranged in March from a lending syndicate headed by Deutsche Bank AG.

While about 85 percent of Blackstone?s renovated homes were leased, Gray said, ?we?ve got an awful lot of homes to continue renovating.?

Sounds like whistling in the dark to me. But Blackstone has a record of continuing to buy at the peak, famously evidenced in the last cycle by buying Equity Office Trust from Sam Zell in February 2007. And that?s not as irrational as it sounds. Blackstone will make money regardless of how its investors do, and it has such an established brand name that it is virtually immune to its own performance (remember how John Meriwether, former head of LTCM, has become a serial fund manager failure yet can still raise money).

Further complicating the picture of a profitable exit is the Fed?s talk of ending QE. Even if the central bank has overestimated the pace of ?recovery?, the mere talk of ending QE has put the mortgage market in a swoon. Fixed-rate mortgages reached their highest interest rate in a year last week and with the increase in Treasury yields this week, are almost certainly higher. This might complicate their plans to have homebuyers take them out. Even if banks loosen underwriting standard (which are tight right now), it won?t take all that much in the way of mortgage rate increases to reduce affordability (the PE funds are more likely to exit via selling the operating company that owns and manages the rentals in an IPO, but the experts thought you needed 1000 homes or so for that to be attractive, which is well beyond the scale of the small fry).

Many of these players have a had a great ride being long real estate in many forms over the last few year. How well the market fares when they choose to cash in their chips is very much an open question. I would not want to be on the other side of their trade.

Source: http://www.nakedcapitalism.com/2013/05/so-who-is-the-dumb-money-ruining-the-housing-rental-market.html

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Saturday, June 1, 2013

Programacion variada ? Marketing With Video 101: Ideas So It Will ...

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You will end up more respectable by the customers in the event the videos are interpreted properly and are really easy to comprehend. The words ?keep it genuine? applies to videos as well. Viewers discover dialog far more credible once the truth. Individuals are most likely to talk about your videos should you not seem honest. Let the viewer determine what you?re providing in advance. Speak about it inside the video?s outline as well as as soon as the video. Should they correspond with whatever they pick up or see, they probably will see the whole thing. When you?ve grasped the standard principles right behind on-line promoting through the Internet, consider starting a Podcast or several regular video lessons. Podcasts have quickly become a remarkably popular useful resource over the past couple of years. You must certain to make make use of this new area of interest to your great advantage. Many audiences like downloading podcasts and observing them whenever they can watch it later. You would like to make sure that your video is entertaining and will support the audiences with superb articles. If you?re unable to do that, you should seriously reconsider your plan of attack. See the video lessons that the rivals. Don?t try to do particularly what they do, but do study from them. See as numerous videos as you can to actually have tips on how to vary from them.


Source: http://progvariada.net/sin-categoria/marketing-with-video-101-ideas-so-it-will-be-job/

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