Friday, November 30, 2012

Emerging vector-borne diseases create new public health challenges

ScienceDaily (Nov. 30, 2012) ? West Nile virus, Lyme disease, dengue fever, and plague are examples of "vector-borne zoonotic diseases," caused by pathogens that naturally infect wildlife and are transmitted to humans by vectors such as mosquitoes or ticks.

According to Marm Kilpatrick, who studies the ecology of infectious diseases at the University of California, Santa Cruz, a broad range of human activities can affect the spread of zoonotic diseases. In an article in the December 1 issue of the British medical journal Lancet, Kilpatrick and coauthor Sarah Randolph of the University of Oxford describe how widespread land-use change, globalization of trade and travel, and social upheaval are driving the emergence of zoonotic vector-borne diseases around the world. The article is part of a special series of papers focused on emerging zoonotic diseases.

"This collection of papers offers a bridge between ecologists and clinicians whose combined efforts are needed to address the ongoing challenges of emerging zoonotic diseases," said Kilpatrick, an assistant professor of ecology and evolutionary biology at UC Santa Cruz.

Emerging infectious diseases can be roughly split between introduced and locally emerging diseases. Introduced diseases arise from the spread of a pathogen to a new location, as when West Nile virus arrived in New York in 1999 and subsequently spread across North America. Locally emerging diseases increase in importance in areas where they are endemic, as with Lyme disease in the United States over the past three decades. These two types of emerging diseases can differ markedly with respect to infection dynamics, or the number of cases over time, Kilpatrick said.

"Introduced diseases often cause a big spike in infections and then decrease substantially. Locally emerging diseases often show a steady, sustained increase," he said.

The movement of pathogens by global trade and travel results in the emergence of diseases in new regions. Once established, introduced pathogens often evolve to take advantage of their new environment, including new hosts and vectors. With so much of the landscape shaped by human activities, pathogens may thrive by infecting hosts and vectors that do well in humanmade environments.

"Increasing human population and the urbanization and agricultural intensification of landscapes puts strong selective pressure on vector-borne pathogens to infect humans and be transmitted by vectors and hosts that live around humans," Kilpatrick said.

Emergence of endemic vector-borne diseases can result from changes in land use, such as expansion of people into new habitats, or environmental changes affecting the wild animals that serve as natural hosts or the insect vectors that spread the disease to humans. Although vector-borne diseases are highly sensitive to climate, climate change does not appear to be a major driving force behind emerging diseases, the authors said.

"So far, climate change has been a relatively minor player compared to land use and socioeconomic factors in the emergence of vector-borne disease," Kilpatrick said.

Social and economic changes, ranging from economic downturns to displacement of populations by armed conflict, frequently precipitate disease outbreaks through their impacts on public health systems, sanitation systems, behavioral patterns, and uses of natural environmental resources. One example cited in the article is a large upsurge of tick-borne encephalitis after an economic downturn in eastern Europe resulted in more people harvesting food from forests.

The incidence of any vector-borne disease involves a complex interplay of multiple factors affecting animal hosts, vectors, and people. Kilpatrick and Randolph emphasize that control of these diseases requires combined efforts by clinicians and public health officials to treat patients, promote behavior likely to minimize the risk of infection, and advise on efforts to reverse the ecological drivers of transmission through vector control, urban planning, and ecological restoration.

Publication of the Lancet series coincides with an Institute of Medicine (IOM) symposium on Emerging Infections, Microbial Threats to Health, and the Microbiome, December 11-12 in Washington, D.C. The symposium marks the 20th anniversary of an influential 1992 IOM report on emerging diseases.

"Humans are altering the environment and moving themselves and other organisms around the globe at an ever-increasing pace," said Sam Scheiner, program director for the Ecology and Evolution of Infectious Diseases program at the National Science Foundation (NSF), a joint effort with the National Institutes of Health (NIH). "That has led to a growing disease threat. These papers show how and why that's happening, and what we need to know to ease the disease burden."

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The above story is reprinted from materials provided by University of California - Santa Cruz. The original article was written by Tim Stephens.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A Marm Kilpatrick, Sarah E Randolph. Drivers, dynamics, and control of emerging vector-borne zoonotic diseases. The Lancet, 2012; 380 (9857): 1946 DOI: 10.1016/S0140-6736(12)61151-9

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/kFn4ZbavZZw/121130151653.htm

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The New Baby Boomers | Latest online News|Breaking news|Daily ...

* Baby numbers hit 118 year peak during crash * Families growing despite falling incomes * Poor jobs market prompts some women to take career break * Growing population will help ease pension squeeze By Conor Humphries and Lorraine Turner DUBLIN, Nov 27 (Reuters) ? Within months of Ireland?s property bubble bursting, estate agent Grainne Bird-Thistle got caught up in the country?s next boom: babies. The number of births in Ireland hit a 118-year high in 2009, when the economy clocked up its worst year on record, and the number of new arrivals has remained close to that peak despite the struggle to emerge from financial crisis. For some, the dark economic clouds have been a spur, as diminished career opportunities and cheaper rents and house prices give them more space to start families. ?During the boom you couldn?t afford to have a mortgage unless you had two jobs and worked really long hours,? said Bird-Thistle, 39, as she left an appointment at Dublin?s main maternity hospital before the birth of her second child. ?If the market is slowing down, why not raise a family? It?s a brilliant opportunity.? Along with half-finished office blocks and vast queues at employment fairs, packed playgrounds and rows of buggies at the entrance to cafes have become familiar signs of the post Celtic Tiger Ireland. In 2009, two years into the crisis, births hit 75,554, ten thousand more than in 2006 when champagne cocktails still flowed in central Dublin bars and then Prime Minister Bertie Ahern infamously noted ?The boom is getting boomier.? Despite one of the highest unemployment rates in Europe, Ireland?s birth rate has remained high, with 74,650 babies born last year compared to an annual average of around 65,500 during the Celtic Tiger. The country?s maternity hospitals, suffering from budget cuts imposed under an EU-IMF bailout, often struggle to cope. ?Our biggest problem is not being able to fill vacancies,? said Dublin midwife Sinead Cleary. ?You end up stealing nurses from other wards to bulk the numbers on the delivery suites.? ?It?s not as busy as 2009 but we are still very busy. In a 24 hour period we could have 18 or 20 deliveries.? In the Dublin-based national maternity hospital, every space in the 19th century building has been gobbled up to provide more delivery suites with some ante-natal clinics held in temporary buildings in the car park. NEVER ENOUGH MONEY The birth rate is good news for Ireland, helping to compensate for the re-emergence of emigration during the crisis with almost 250 people, most of them in their twenties, leaving the country every day. The higher birth rate prompted the central statistics office last year to forecast population growth of more than 8 percent in five years, around four times the EU average. The EU statistics agency last year predicted Ireland?s population would increase by almost a quarter over the next 25 years, compared to a rise of just under 5 percent in the EU as a whole. ?It means the problem of old age dependency will rise more slowly than previously anticipated and much more slowly than in the rest of the EU,? said John Fitzgerald, research professor at the Economic and Social Research Institute think tank. ?A lot of concerns are about pensions and so on, those problems are going to rise definitely in the long term but they will rise by less.? Ireland has the highest fertility rate in the European Union with just over two births per woman on average, in part due to a surge in women of child-bearing age after an earlier baby boom during the late 1970s and early 1980s, when the country was also gripped by economic crisis. But career breaks forced by the collapse of swathes of the economy and lower child costs have also played a role. ?During the boom when my wife was working we were more money focused. When you lose your job your focus changes,? said Paul Meade, 30, an insurance broker, whose wife had her first baby after losing her job in a construction company in 2010. ?We thought about the money of course, but I don?t know if you ever have enough money for it,? he said, taking his 19-month old son for a walk while his wife had an ante-natal check up. While Ireland has seen the largest contraction of GDP in the euro area since the crisis began, it is the third richest country according to EU figures ? so a contraction in living standards has not placed as many families in poverty. The government?s monthly payment to parents has fallen to 140 euros a month from 160 euros at the height of the boom still higher than many other parts of Europe, including the Britain. ?I went home a few weeks ago and I didn?t see one baby. Here they are everywhere,? said Alice, a 32-year-old pregnant Romanian living in Dublin. She said higher living standards of meant families could more easily cope with falls in income. Immigrants, most of whom arrived in the final years of the Celtic Tiger boom, have also played a role with almost a quarter of babies born to non-Irish nationals in 2010. IRISH PHENOMENON With thousands of families stuck in small apartments, starter homes that became negative equity traps when house prices fell, some are putting off having children until the economy improves. A survey of 700 women by Amarach research found 39 percent saying the recession had played a role in not increasing their family size. But many are just planning families to fit into their more limited budgets. ?It?s more prams but cheaper prams,? said Paul Kealy, owner of the Tony Kealys baby stores, who said the crisis had forced retailers to cut prices on premium models. ?People are having more babies but they are spending less money.? Like other Catholic countries, Ireland has traditionally had larger families than the European average, with families of 10 or more not uncommon in the earlier 20th century. While they have shrunk in the decades since, they remain among the largest in Europe. ?The middle class family with four children is a uniquely Irish phenomenon in a European context,? said Victoria White, a Dublin-based mother of 4 and author on parenthood. ?A lot of us do equate happiness with a larger family.? If birth rates were an economic indicator, Ireland would be roaring ahead, she said. ?The markets should be looking at it and saying, maybe the mothers of Ireland know something.?

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Source: http://latest-newsonline.com/business-and-finance-news/the-new-baby-boomers/

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Will Hugh Jackman return as Wolverine in 'X-Men: Days of Future Past'?

Hugh Jackman portrayed Wolverine in the first three 'X-Men' films as well as one spin-off and will already reprise the role in another 2013 spin-off.

By Rob Keyes,?Screen Rant / November 29, 2012

Hugh Jackman is already set to play Wolverine in the upcoming 2013 film 'The Wolverine.'

Kim Hong-Ji/Reuters

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The pieces are falling into place, forming what may eventually become an all-out reunion for Bryan Singer and the casts of both the?X-Men trilogy and its prequel,?X-Men: First Class. We?ve known the potential of returning appearances of familiar characters since Singer confirmed the film?s title,?X-Men: Days of Future Past, based on the title of the famous time-travel story arc from Marvel Comics, but it wasn?t until yesterday did we learn it?s actually happening.

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Screen Rant had a humble start back in 2003 as a place to rant about some of the dumber stuff related to the movie industry. Since then, the site has grown to cover more and more TV and movie news (and not just the dumb stuff) along with sometimes controversial movie reviews. The goal at Screen Rant is to cover stories and review movies from a middle ground/average person perspective.

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Bryan Singer ? taking over the director?s seat from Matthew Vaughn who may or may not be directing?Star Wars Episode 7 ? happily confirmed that?Patrick Stewart and Ian McKellen will be back for the next?X-Men team-up and as we suspected, they will likely be joined by franchise star Hugh Jackman.

According to?THR, Jackman is currently in negotiations with Fox to return for what will be his sixth portrayal of the adamantium-laced feral mutant (the seventh being a cameo in?X-Men: First Class). This would further solidify his status as the actor who holds the record for playing the same superhero character in the most films.

Jackman?loves playing Wolverine and previously went on record saying he?s not in it for the money. He?s even producing?The Wolverine, which tells the tale of Logan?s travels to Japan ? a story that Jackman wanted to be a part of ever since he joined?X-Men. Three years ago, when?X-Men Origins: Wolverine debuted, he jokingly said he?d play the character ?eleven more? times.

?I always say, ?oh, I?m never doing another one,? until I see the script. It has to be something. But in the superhero world, those kind of movies, ?Wolverine? is by far the most interesting? So I?ll do eleven more and that?s it!?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/RypLggF7AN0/Will-Hugh-Jackman-return-as-Wolverine-in-X-Men-Days-of-Future-Past

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Thursday, November 29, 2012

HFF Closes $107M Sale of Office Portfolio in Boston's Seaport District

November 29, 2012

By Gail Kalinoski, Contributing Editor

HFF has been involved with another multimillion dollar deal in Boston?s Seaport District, an up and coming area along the South Boston waterfront, with the $106.75 million sale of a four-property portfolio to DivcoWest Properties.

Senior Managing Director Coleman Benedict and Director Ben Sayles represented the seller, Brickman Associates, and procured the buyer for the collection of ?brick and beam? office buildings that comprise 362,562-square-feet of space. The assets are: Harbor Corporate Center at 300 A St., a 106,171-square-foot building; 313 Congress St., a 70,217-square-foot property; 330 Congress St., a 35,811-square-foot building; and 51 Sleeper St., the largest of the spaces at 150,363 square feet.

HFF also arranged the $31.4 million acquisition financing for 51 Sleeper St., which was led by Eastern Bank. Riaz Cassum, senior managing director, and Lauren O?Neil, director, represented DivcoWest on the financing deal.

The portfolio is located in Fort Point section of Boston?s Seaport District, which is an area growing with both public and private investments.

?The Fort Point Channel is marked by rising tenant demand and diminishing supply,? Benedict said. ?Not surprisingly, investor interest continues to be incredibly strong as the Seaport is one of the nation?s most exciting submarkets.?

The properties were acquired for the DivcoWest Fund III, an $870 million fund raised last year to invest primarily in tech-oriented real estate markets. DivcoWest, founded in 1993, is a privately owned real estate investment firm with offices in Boston and San Francisco. The firm and its affiliates are currently managing more than $2 billion of equity. It has acquired more than 22 million square feet of commercial space throughout the United States, including over 3 million square feet in the Boston area. Most of its activity this year has been in California, though the fund did buy a Class A office building called The Davenport in Cambridge, Mass., for $79 million in March.

The Seaport District properties are converted warehouse buildings that were used by the Boston Wharf Co. The Congress Street buildings were erected in 1890 and extensively renovated in 1984. The Sleeper Street building was constructed in 1929 and renovated in 2004. Harbor Corporate Center was built in 1904 and renovated in 2004. It was described as ?one of the highest quality ?brick and beam? assets in the market,? by DivcoWest officials.

?These are all buildings with great bones in a dynamic submarket of Boston that is rapidly growing in its appeal for companies seeking creative workplace environments,? said Stuart Shiff, CEO of DivcoWest.

Brickman is a 20-year-old real estate private equity firm. It currently owns and manages more than 3 million square feet of office space. The firm bought the portfolio in three purchases between March 2006 and May 2007. It has invested more than $3 billion in more than 70 real estate transactions.

HFF is the leading provider of commercial real estate and capital markets services, including debt and equity placement, investment sales, loan sales and commercial loan services.

Earlier this fall, HFF secured a $170 million construction loan for One Channel Center, an 11-story, 500,000-square-foot Class A office building in the Seaport District for its developers, AREA Property Owners and Commonwealth Ventures L.L.C. The building will be fully leased by State Street Corp. and is expected to be completed by early 2014.

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Source: http://www.cpexecutive.com/regions/mid-atlantic/hff-closes-107m-sale-of-office-portfolio-in-bostons-seaport-district/

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GMail integrates with Google Drive, Outlook.com comes to Android


Competition - is good for customers. When competition is strong, vendors stop being lazy and even forget about their political principles. And we've got the very interesting competition here: GMail vs Outlook.com. Microsoft recently turned its "mail for blondes" Hotmail into a solid and practical Outlook.com and now (as Microsoft says) it entices GMail users every day. Outlook.com advantages over GMail (according to Microsoft) are better spam protection and cleaner design. And different GMail features (discussion threads, hotkeys, themes ...) are gradually coming to Outlook.com. Today Outlook.com added an Android-application. Of course Android - is the competing platform, and so what?


And Google has finally stopped being lazy and implemented integration between GMail and Google Drive. Now you can send files stored on your online drive via GMail. In particular, it allows you to quickly send files up to 10 GB. Perhaps the reason for this step was that Outlook.com can send large files via SkyDrive. However, in GMail's option has one drawback compared to Outlook.com: in order to download the file recipient must have a Google-account.

Source: http://feedproxy.google.com/~r/liventerprise/~3/xLgzFn0Pi5I/

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Commodities: Crude Oil, Gold May Find Support on US Recovery Hopes

DailyFX

Crude oil and gold are under pressure in European trade but prices may find support as US economic data and the Fed's Beige Book boost risk appetite.

Talking Points

  • Commodities Sold with Risk Trends on OECD "Fiscal Cliff" Warning
  • US New Home Sales Data, Fed Beige Book May Offer Tentative Support

Commodities under pressure in early European trade, with the newswires citing ominous comments from the OECD warning a global recession could follow a failure to avert the US fiscal cliff as the catalyst. S&P 500 stock index futures are pointing lower, hinting more of the same is on tap as Wall Street comes online. The day's economic data docket may help offset near-term negativity however.

First, preliminary set of November's German CPI figures is expected to see the headline inflation rate drop to 1.9 percent, the lowest in four months. This may be seen as giving the ECB additional room to ease monetary policy, which bodes well for sentiment considering the recession in the Eurozone represents the most significant headwind presently facing global growth.

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Later in the day, US New Home Sales are expected to hit 390,000 in October, marking the highest reading since April 2010. The Fed's Beige Book survey of regional economic conditions is also on tap. Signs of firming growth in the world's largest economy are likely to buoy overall risk appetite amid hopes it will be better able to counterbalance sluggish performance in Europe and Asia.

A recovery in sentiment is likely to boost growth-geared crude oil and copper prices, where near-term correlations with share prices remain significant. Meanwhile, gold and silver may find de-facto support as swelling risk appetite dents haven demand for the US Dollar.

WTI Crude Oil (NY Close): $87.18 // -0.56 // -0.64%

Prices are consolidating below resistance at 89.48, the 23.6% Fibonacci expansion. Initial rising trend line support is at 87.17, with a break below that on a daily closing basis exposing the November 7 low at 84.04. Alternatively, a push above resistance targets the 38.2% level at 92.88.

Commodities_Crude_Oil_Gold_May_Find_Support_on_US_Recovery_Hopes_body_Picture_4.png, Commodities: Crude Oil, Gold May Find Support on US Recovery Hopes

Daily Chart - Created Using FXCM Marketscope 2.0

Spot Gold (NY Close): $1742.15 // -6.50 // -0.37%

Prices appear to have carved out a bullish Inverse Head and Shoulders chart pattern confirmed with a close above neckline resistance at 1737.28, 23.6% Fibonacci retracement. The setup implies a measured upside target at 1802.06. The 1737.28 level has been recast as near-term support, with a break below that aiming for the 38.2% Fib at 1688.65.

Commodities_Crude_Oil_Gold_May_Find_Support_on_US_Recovery_Hopes_body_Picture_3.png, Commodities: Crude Oil, Gold May Find Support on US Recovery Hopes

Daily Chart - Created Using FXCM Marketscope 2.0

Want to learn more about RSI? Watch this Video

Spot Silver (NY Close): $34.06 // -0.10 // -0.29%

Prices are testing resistance at 34.18, the 38.2% Fibonacci expansion. A break above that exposes the 50% level at 35.29. Near-term rising trend line support is at 33.12 and is reinforced by the 23.6% Fib at 32.84. A drop below the latter level aims for the November 5 low at 30.65.

Commodities_Crude_Oil_Gold_May_Find_Support_on_US_Recovery_Hopes_body_Picture_2.png, Commodities: Crude Oil, Gold May Find Support on US Recovery Hopes

Daily Chart - Created Using FXCM Marketscope 2.0

Want to learn more about RSI? Watch this Video

COMEX E-Mini Copper (NY Close): $3.536 // 0.000 // 0.00%

Prices are consolidating below resistance at 3.540, the 38.2% Fibonacci retracement. Initial support lines up at 3.487, the 23.6% level, with a break below that aiming for rising trend line support at 3.414. Alternatively, push above 3.540 targets the 50% Fib at 3.588.

Commodities_Crude_Oil_Gold_May_Find_Support_on_US_Recovery_Hopes_body_Picture_1.png, Commodities: Crude Oil, Gold May Find Support on US Recovery Hopes

Daily Chart - Created Using FXCM Marketscope 2.0

--- Written by Ilya Spivak, Currency Strategist for Dailyfx.com

To contact Ilya, e-mail ispivak@dailyfx.com. Follow Ilya on Twitter at @IlyaSpivak

Source: http://www.ibtimes.co.uk/articles/409370/20121128/commodities-crude-oil-gold-find-support-recovery.htm

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ANALYST: Facebook Is About To Fill Instagram ... - Business Insider

Sterne Agee analysts Arvind Bhatia and Brett Strauser have increased their target price for Facebook stock to $32 based on what they believe is the impending "monetization" of Instagram, the photosharing service Facebook bought for $1 billion before its IPO.

Their theory is that Facebook's recent tweak of its terms of service paves the way to allow advertisers to buy space in Instagram users' photostreams.

Here's the relevant section from their note to investors today:

Instagram Monetization Coming Soon? Facebook recently proposed changes to its data use policy and statement of rights and responsibilities that will, in short, enable the company to share information with affiliates like Instagram. While the monetization of Instagram is something investors largely expect, the main question has been the timing. This change could be an indication that Facebook is planning to monetize Instragram in the near future, as it would allow Instagram to use Facebook?s data to personalize the Instagram user experience and perhaps target advertisements. We note that Instagram currently has approximately 39M monthly active users, according to AppData. We believe most estimates currently do not factor Instagram monetization yet due to the uncertainty on the timing.

Source: http://www.businessinsider.com/analyst-facebook-is-about-to-fill-instagram-full-of-ads-2012-11

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Wednesday, November 28, 2012

Historic Trauma: The Enduring Health of Ronald Reagan on ...




Popular speaker and author Cindy Blank-Reid, RN, reviews the health record of Ronald W. Reagan who at the age of 70 was the?oldest individual ever elected to the Oval Office.?Thirty years after he was elected, his?name has resurfaced due to his?beliefs, speeches?and plans he implemented. Just 69?days into?his presidency, Reagan sustained a gunshot wound to the?chest in an?assassination attempt which resulted in?both?pulmonary and?vascular injuries.?Despite his age, he?made a remarkable recovery.?After his presidency in 1989, Reagan suffered from a subdural hematoma?when he was thrown from a horse.?In?1994, at the age of 83, Reagan was diagnosed with?Alzheimer's disease. He sustained a fractured hip in 2001 and died in 2004 at the age of 93 from pneumonia.

Of note, Reagan started wearing hearing aids during his presidency; he went public with the news in 1983. Also during his presidency, he had cancerous polyps removed from his colon;?skin cancer removed from his nose; and had surgery for enlarged prostate.

Join us for this FREE live webinar to learn more.

When: Tuesday, Dec. 11, 1:00-2:00 p.m. ET
Where: Your computer*
Presenter: Cynthia Blank-Reid, MSN, RN, CEN
Cost: Free
Who Should Attend: Anyone interested in discussing complex health issues and what they teach us.
How: Register Here

About the presenter: Cynthia Blank-Reid is a trauma clinical nurse specialist in Philadelphia. She speaks nationally on historic trauma cases and writes frequently for ADVANCE. Look for articles from her in 2013.

Register now!

*The audio portion of the webinar is available through your computer's speakers or a phone line. A phone number and passcode will be provided at the beginning of the webinar.

Source: http://physical-therapy.advanceweb.com/Webinar/Editorial-Webinars/Historic-Trauma-The-Enduring-Health-of-Ronald-Reagan.aspx

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Windows 8 sales hit 40 million

Microsoft said Tuesday it sold 40 million licenses for its Windows 8 operating system in the first month after a launch which got a mixed reception.

One of the new heads of the Windows unit, Tami Reller, made the announcement to an analysts' meeting and Microsoft provided the information on its Windows blog.

"Windows 8 is outpacing Windows 7 in terms of upgrades," the blog post said. "We built Windows 8 to work great on existing Windows 7 PCs. And we also set out to make upgrading from Windows 7 to Windows 8 super easy."

Microsoft released the new operating system worldwide on October 26 as a way to help the dominant PC software maker get a bigger share of the market for mobile devices such as tablets.

But some say the new system may be hard to adapt to both PC and tablet format and that businesses may be slow to adopt Windows 8.

It's not clear how many people are using Windows 8, because the licenses may be sold to PC makers and not yet in use.

Earlier this month, Microsoft said the head of its Windows unit was leaving.

Windows president Steven Sinofsky will depart Microsoft and, effective immediately, his duties will be divided between a pair of executives who will answer directly to chief executive Steven Ballmer.

Julie Larson-Green was promoted to lead Windows software and hardware engineering. Reller will run the business side of Windows in addition to her duties as chief financial officer.

Microsoft has not disclosed sales data for its new Surface tablet computer, which uses Windows 8, and was launched at the same time as the operating system.

The Redmond, Washington giant said it was also boosting the number of apps in its Windows Store as part of its mobile strategy.

"There were more apps in the Windows Store at launch than any other app store at their launch and since then, the number of apps in the Windows Store has doubled," the blog said.

"A number of apps in the Windows Store have crossed the $25,000 revenue mark and the developer keeps 80 percent of the revenue they make off downloads for the life of their app. A lot of great new apps have been added to the Windows Store since launch."

(c) 2012 AFP

Source: http://phys.org/news273260055.html

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Tuesday, November 27, 2012

Tech Tuesday: Free & Almost Free Ways to Advertise Online 11/27 ...

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    On his show, Comedian Rodney Perry covers arts and entertainment, everything from comedy and politics to music and acting, with his signature comedic slant.

  • MashUp Radio is a 30-minute podcast that discusses the fusion of technology, life, culture and science. Host Peter Biddle, engineer and executive for Intel?s Atom Software, dishes up a thought-provoking discussion.

  • Joy Keys provides her listeners with insight to improve their lives mentally, physically, monetarily and emotionally. Past guests on the show have included Meshell Nedegeocello, Blair Underwood, in addition to an impressive list of CEOs, humanitarians and authors.

  • Host Barry Moltz gets small businesses unstuck. He has founded and run small businesses with a great deal of success and failure for more than 15 years. This is a business radio show where he shares all the craziness of small business. It?s that craziness that actually makes it exciting, interesting and totally unpredictable.

  • The Bottom Line Sports Show is hosted by former NBA stars Penny Hardaway, Charles Oakley, Mateen Cleaves. Tune in to get the inside scoop on what's happening in sports today.

  • Deepak Chopra Radio provides an online forum for compelling and thought provoking conversations on success, love, sexuality and relationships, well-being and spirituality.

  • Hits Radio covers basketball, sports culture and entertainment with past guests including Jason Kidd, Robin Lundberg and Chris Herren.

  • Listeners get an earful on The Halli Casser-Jayne Show, Talk Radio for Fine Minds. Whether it?s the current political cocktail or the latest must-read award-winning book, Halli tackles all topics and likes to stir ? and sometimes shakes ? things up.

  • Award-winning World Footprints is a leading voice in socially responsible travel and lifestyle. Hosts Ian & Tonya celebrate culture and heritage and bring a unique voice to the world of travel.

  • Football Reporters Online is a group of veteran football experts in the fields of coaching, scouting, talent evaluation, and writing/broadcasting/media placement. Combined, the group brings well over 100 years of expertise in sports.

  • Host John Martin interviews the nation's leading entrepreneurs and small biz experts to educate small business owners on how to be successful. Past guests have included Emeril Lagasse and Guy Kawasaki.

  • The Movie Geeks share their passion for the art through interviews with the stars of and creative minds behind your favorite flicks and pay tribute to big-screen legends. From James Cameron and Francis Ford Coppola to Ellen Burstyn and Robert Duvall, The Geeks have got'em all.

  • Sylvia Global presents global conversations pertaining to women, wealth, business, faith and philanthropy. Sylvia has interviewed an eclectic mix from CEOs and musicians to fashion designers and philanthropists including Randolph Duke and Ne-Yo.

  • Seasoned entertainment reporter Robin Milling gets up close and personal with the world's most compelling celebs. From Michael Douglas to Katie Holmes to Kevin Kline to Ashley Judd to America Ferrera, she sits down in person each week with each and every A-lister.

  • Mr. Media host Bob Andelman goes one-on-one with the hottest, most influential minds from the worlds of film, TV, music, comedy, journalism and literature. That means A-listers like Kirk Douglas, Christian Slater, Kathy Ireland, Rick Fox, Chris Hansen and Jackie Collins.

  • Paula Begoun, best-selling author of Don't Go to the Cosmetics Counter Without Me, separates fact from fiction on achieving a radiant, youthful complexion at any age. She?s regularly joined by health and beauty experts who offer the latest on keeping your skin in tip-top shape.

  • Source: http://www.blogtalkradio.com/caribbeanradioshow/2012/11/28/tech-tuesday-free-almost-free-ways-to-advertise-online

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    Source: http://dancingmom72.blogspot.com/2012/11/gaylesbian-relationships.html

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    Source: http://annesharma48.blogspot.com/2012/11/gaylesbian-relationships-new-beginnings.html

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    Using biomarkers from prehistoric human feces to track settlement and agriculture

    ScienceDaily (Nov. 26, 2012) ? For researchers who study Earth's past environment, disentangling the effects of climate change from those related to human activities is a major challenge, but now University of Massachusetts Amherst geoscientists have used a biomarker from human feces in a completely new way to establish the first human presence, the arrival of grazing animals and human population dynamics in a landscape.

    Doctoral student Robert D'Anjou and his advisor Raymond Bradley, director of the Climate System Research Center at UMass Amherst, with UMass colleagues Nick Balascio and David Finkelstein, describe their findings in the current online edition of Proceedings of the National Academy of Sciences.

    "We are really excited about how well this method worked," D'Anjou says. "Without even knowing it, early settlers were recording their history for us, and in the most unlikely of ways, in their poop. The prehistoric settlers and their livestock pooped and their feces washed into the lake, which over time left a record of trace amounts of specific molecules that are only produced in the intestines of higher mammals. When you find these molecules at certain concentrations and in specific ratios, it provides an unmistakable indicator that people were living in the area."

    Bradley adds, "This approach opens the door to other studies, where the presence of humans is uncertain; we believe it has great potential for much wider applications in archaeology."

    D'Anjou carried out the work just north of the Arctic Circle, at Lake Liland in the Lofoten Islands in northern Norway, where humans were thought to have lived in prehistoric settlements from the early Iron Age through the Viking period. They extracted two sediment cores from the lake bottom and used radiocarbon measurements and the presence of volcanic ash from Iceland to establish their chronology. The sediments provided a continuous record extending back roughly 7,000 years.

    Paleoclimatologists have long used markers in lakebed sediments, such as charcoal from humans' fires and pollen from cultivated plants, as a natural archive of environmental changes to estimate when humans first began having an impact. But these indirect indicators must be used with care when reconstructing the history of a place because it's not always clear that they indicate human activity in the same area.

    By contrast, the presence of a molecular biomarker directly linked to humans, one transmitted through their bowel movements, offers "a strong human signal," as the authors put it, one that can be dated with "excellent chronological control." D'Anjou and colleagues extracted the compound coprostanol, a molecular marker formed from the digestion of cholesterol in the human gut, from the sediment, plus other sterols characteristic of other mammals to estimate the presence of sheep and cattle. From these, they were able to produce a long-term record of the presence and relative population size of humans extending back over thousands of years at the site.

    In addition, the geoscientists used two other molecular markers to reconstruct the vegetation history: relative length of carbon molecules found in leaf waxes (different in forest and grassland), and pyrolytic polycyclic aromatic hydrocarbons (PAH) as evidence of fire in the Lake Liland area. They say that taken together, the sediment cores, vegetation changes and fire records clearly define a pre-settlement period with no detectable human activity in the lake's water catchment area from about 7,300 to 2,250 years ago.

    At that point, however, changes in the background state appear in the record, marking an "abrupt shift" to significantly increased levels of pyrolytic PAH first, followed by increased human fecal material. This likely indicates that as people moved in, they first cleared the land by burning before establishing a permanent settlement, the researchers say. "This interpretation is bolstered," they add, by the leaf wax record that shows a "marked transition to a more grassland-dominated landscape beginning at this time."

    After the initial influx of people to the region, D'Anjou and colleagues say the record shows a lull in human activity from about 2,040 to 1,900 years ago, reflected in all markers. After this, the human and livestock populations steadily increased to a local maximum around the year 500, based on the fecal record, then fell again to a second minimum around the year 850.

    The climate scientists note a further decline in human activity and population to another minimum at about AD 1750 that coincided with the highest relative grassland cover for the entire 7,300-year history. Findings related to human activity over the past 7,300 years in northern Norway correlate well with other climate reconstructions, in particular summer temperature patterns indicating poor vs. fruitful growing seasons. This shows that the early settlers were vulnerable to small changes in summer temperature at this far northern location.

    Overall, the authors say, the new fecal markers are likely to prove valuable in many other places, to distinguish natural from human factors that influenced the environment in the past.

    Share this story on Facebook, Twitter, and Google:

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    Story Source:

    The above story is reprinted from materials provided by University of Massachusetts at Amherst, via EurekAlert!, a service of AAAS.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Robert M. D?Anjou, Raymond S. Bradley, Nicholas L. Balascio, and David B. Finkelstein. Climate impacts on human settlement and agricultural activities in northern Norway revealed through sediment biogeochemistry. PNAS, November 26, 2012 DOI: 10.1073/pnas.1212730109

    Note: If no author is given, the source is cited instead.

    Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/a4plpf3KC-c/121126151049.htm

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    Monday, November 26, 2012

    Give the Gift That Gets People Talking ? Cyber Monday Special ...

    Give the Gift That Gets People Talking ? Cyber Monday?Special!

    If you?re looking to get your Holiday shopping done early, then today is your lucky day. Check out some of the great deals we?re offering below, and give the gift that gets people talking!

    Dragon Home Holiday Bundle

    It?s all about friends and family with our exclusive Dragon Home Holiday Bundle. This package features Dragon NaturallySpeaking 12 Home, the fast, fun and convenient way to interact with your PC using your voice. Dictate documents, send email, search the Web, and more ? with simple voice commands. There?s no easier or more enjoyable way to capture creativity and get more done on your PC.

    Here?s what you get:

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    Price: $74.99, a $155 retail value!

    Dragon Premium Holiday Bundle

    This holiday, we?re making it all about friends and family with our exclusive Dragon Premium Holiday Bundle. This package features Dragon NaturallySpeaking 12 Premium edition to let you get through your ?to?do? list faster than ever before ? by talking! Dictate or modify documents, spreadsheets and presentations, send email, search the Web, and more. Even capture notes on the go using a digital recorder and Dragon will transcribe the audio files back at your PC.

    We?ve combined our best-selling speech recognition with Family Tree Maker? Workshop 2, genealogy software that will bring your family history to life with photos, historical records and interactive maps. We finish this package off with our USB headset.

    Dragon speech recognition makes a great gift, so ignite new possibilities for your friends and family this holiday season.

    Here?s what you get:

    • Package includes Dragon Premium Edition speech recognition software
    • Family Tree Maker genealogy software
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    Price: $149.99 a $255 retail value!

    Dragon Dictate Holiday Bundle

    This holiday, we?re making it all about friends and family with our exclusive Dragon Dictate for Mac Holiday Bundle. Our holiday package features Dragon Dictate for Mac 3 speech recognition software, which lets you use your voice to create and edit text or interact with your favorite Mac applications. You can even use a digital voice recorder and Dragon will transcribe your dictation when you are back at your Mac.

    We?ve combined our best-selling speech recognition with Family Tree Maker? Workshop 2, genealogy software that will bring your family history to life with photos, historical records and interactive maps and more. We finish this package off with our USB headset.

    Dragon speech recognition makes a great gift, so ignite new possibilities for your friends and family this holiday season.

    Here?s what you get:

    • Package includes Dragon Dictate for Mac speech recognition software
    • Family Tree Maker genealogy software
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    Price: $149.99?a$255 retail value

    Like this:

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    Source: http://voicesofdragon.com/2012/11/26/give-the-gift-that-gets-people-talking-cyber-monday-special/

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    Apple Throws a Tantrum After Being Ordered to Tell Samsung Their HTC Secrets

    DEAR ABBY: My darling mother-in-law passed away recently. She was a wonderful woman, a caring and loving role model to her children and grandchildren. In her will she left a diamond ring to her daughter, "Mimi," a diamond ring to me, and the remainder of her jewelry to her grandchildren. Her house and its contents were to be divided equally between her son and daughter.My children received a box from Mimi filled with Mom's costume jewelry. All of her expensive jewelry was missing. When I asked about the missing items, Mimi said they were in the box, and she had taken photos to prove it. ...

    Source: http://news.yahoo.com/apple-throws-tantrum-being-ordered-tell-samsung-htc-001121226.html

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    Three bodies found in Dallas motel

    By Kevin Cokely, NBCDFW.com

    Police are looking for the motive and suspects behind the fatal shooting of three people found dead at a north Dallas motel.

    A cleaning crew discovered the bodies of two men and a woman at a Motel 6, just north of the High 5 interchange of Central Expressway and I-635 LBJ Freeway, just before noon on Saturday.

    See more at NBCDFW.com

    The two male victims and one female victim had been shot to death. Their names have not been released.

    Dallas Police are investigating but have no motive or suspects as of Saturday evening.

    ?

    Source: http://usnews.nbcnews.com/_news/2012/11/25/15426328-three-shooting-victims-found-in-dallas-texas-motel-room?lite

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    Sunday, November 25, 2012

    larafawcatt: Daily Tips for Business: Industrial-Mechanical - Typepad

    Photochemical etching, one of the manufacturing world's best-kept secrets, produces highly accurate, identical pieces for both large and small-scale operations. Photochemical etching in used in a variety of industries including: automotive, communications, electronics and precision engineering. The process can produce one off designs, to large batches of identical pieces.

    Source: http://dailytipsforbusiness.blogspot.com/2012/11/industrial-mechanical_20.html

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    Source: http://larafawcatt.blogspot.com/2012/11/daily-tips-for-business-industrial.html

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    Brash boxer 'Macho' Camacho dies in Puerto Rico

    FILE - In this July 7, 2001 file photo, boxing champ Hector "Macho" Camacho acknowledges fans at KeySpan Park in New York's Coney Island. Camacho, a boxer known for skill and flamboyance in the ring, as well as for a messy personal life and run-ins with the police, has died, Saturday, Nov. 24, 2012, after being taken off life support. He was 50. (AP Photo/Stephen Chernin, File)

    FILE - In this July 7, 2001 file photo, boxing champ Hector "Macho" Camacho acknowledges fans at KeySpan Park in New York's Coney Island. Camacho, a boxer known for skill and flamboyance in the ring, as well as for a messy personal life and run-ins with the police, has died, Saturday, Nov. 24, 2012, after being taken off life support. He was 50. (AP Photo/Stephen Chernin, File)

    FILE - In this Dec. 9, 1986 file photo, Hector "Macho" Camacho WBC lightweight boxing champion, is escorted by Marty Cohen, left, and boxing promoter Don King, right, during a news conference in New York. Famed Puerto Rican boxer Camacho is clinically brain dead, doctors said Thursday, Nov. 22, 2012, though they said family members were disagreeing on whether to take him off life support. Dr. Ernesto Torres said doctors have finished performing all medical tests on Camacho, who was shot in the face Tuesday night. (AP Photo/David Bookstaver, File)

    FILE - In this July 11, 1982 file photo, Luis Loy Jr., left, ducks under a blow by Hector Camacho early in a scheduled 10-round junior lightweight boxing bout at Felt Forum in New York. Hector "Macho" Camacho, a boxer known for skill and flamboyance in the ring, as well as for a messy personal life and run-ins with the police, has died, after being taken off life support. He was 50. (AP Photo/Elias, File)

    FILE - In this July 14, 2001 file photo, boxing champ Hector "Macho" Camacho celebrates after defeating Roberto Duran in their super middleweight National Boxing Association championship fight in Denver. Camacho, a boxer known for skill and flamboyance in the ring, as well as for a messy personal life and run-ins with the police, has died, Saturday, Nov. 24, 2012, after being taken off life support. He was 50. (AP Photo/Ed Andrieski, File)

    FILE - In this March 7, 1989 file photo, Hector "Macho" Camacho jumps out of the way of a punch thrown by Ray Mancini during the third round of their WBO Junior Welterweight Championship boxing match in Reno, Nev. Camacho, a boxer known for skill and flamboyance in the ring, as well as for a messy personal life and run-ins with the police, has died, Saturday, Nov. 24, 2012, after being taken off life support. He was 50. (AP Photo/Eric Risberg, File)

    (AP) ? Hector "Macho" Camacho was a brash fighter with a mean jab and an aggressive style, launching himself furiously against some of the biggest names in boxing. And his bad-boy persona was not entirely an act, with a history of legal scrapes that began in his teens and continued throughout his life.

    The man who once starred at the pinnacle of boxing, winning several world titles, died Saturday back in the Puerto Rican town of Bayamon where he was born, ambushed in a parking lot in a car where packets of cocaine were found.

    Camacho, 50, left behind a reputation for flamboyance ? leading fans in cheers of "It's Macho time!" before fights ? and for fearsome skills as one of the top fighters of his generation.

    "He excited boxing fans around the world with his inimitable style," promoter Don King told The Associated Press.

    Camacho fought professionally for three decades, from his humble debut against David Brown at New York's Felt Forum in 1980 to an equally forgettable swansong against Saul Duran in Kissimmee, Florida, in 2010.

    In between, he fought some of the biggest stars spanning two eras, including Sugar Ray Leonard, Felix Trinidad, Oscar De La Hoya and Roberto Duran.

    "Hector was a fighter who brought a lot of excitement to boxing," said Ed Brophy, executive director of International the Boxing Hall of Fame. "He was a good champion. Roberto Duran is kind of in a class of his own, but Hector surely was an exciting fighter that gave his all to the sport."

    Camacho's family moved to New York when he was young and he grew up in Spanish Harlem, which at the time was rife with crime. Camacho landed in jail as a teenager before turning to boxing, which for many kids in his neighborhood provided an outlet for their aggression.

    "This is something I've done all my life, you know?" Camacho told The Associated Press after a workout in 2010. "A couple years back, when I was doing it, I was still enjoying it. The competition, to see myself perform. I know I'm at the age that some people can't do this no more."

    Former featherweight champion Juan Laporte, a friend since childhood, described Camacho as "like a little brother who was always getting into trouble," but otherwise combined a friendly nature with a powerful jab.

    "He's a good human being, a good hearted person," Laporte said as he waited with other friends and members of the boxer's family outside the hospital in San Juan after the shooting. "A lot of people think of him as a cocky person but that was his motto ... Inside he was just a kid looking for something."

    Laporte lamented that Camacho never found a mentor to guide him outside the boxing ring.

    "The people around him didn't have the guts or strength to lead him in the right direction," Laporte said. "There was no one strong enough to put a hand on his shoulder and tell him how to do it."

    George Lozada, a longtime friend from New York who flew to Puerto Rico on Saturday, recalled that just hours after he was released from prison after serving a murder sentence, he received a call from Camacho, who was waiting outside his apartment in a black Porsche.

    "He said, 'Come down, I'm taking you shopping,'" Lozada said, wiping away tears.

    "Because of him, man, I got what I got today," he said, pointing to pictures on his smartphone of his 6-year-old daughter. "Because of Hector, I stopped the drug scene ... He's helped so many people."

    Drug, alcohol and other problems trailed Camacho himself after the prime of his boxing career. He was sentenced in 2007 to seven years in prison for the burglary of a computer store in Mississippi. While arresting him on the burglary charge in January 2005, police also found the drug ecstasy.

    A judge eventually suspended all but one year of the sentence and gave Camacho probation. He wound up serving two weeks in jail, though, after violating that probation.

    Camacho's former wife, Amy, obtained a restraining order against him in 1998, alleging he threatened her and one of their children. The couple, who had two children at the time, later divorced.

    He divided his time between Puerto Rico and Florida in recent years, appearing on Spanish-language television as well as on a reality show called "Es Macho Time!" on YouTube.

    Inside the boxing ring, Camacho flourished. He won three Golden Gloves titles as an amateur, and after turning pro, he quickly became a contender with an all-action style reminiscent of other Puerto Rican fighters.

    Long promoted by Don King, Camacho won his first world title by beating Rafael Limon in a super-featherweight bout in Puerto Rico on Aug. 7, 1983. He moved up in weight two years later to capture a lightweight title by defeating Jose Luis Ramirez, and successfully defended the belt against fellow countryman Edwin Rosario.

    The Rosario fight, in which the victorious Camacho still took a savage beating, persuaded him to scale back his ultra-aggressive style in favor of a more cerebral, defensive approach.

    The change in style was a big reason that Camacho, at the time 38-0, lost a close split decision to Greg Haugen at Caesar's Palace in Las Vegas in 1991.

    Camacho won the rematch to set up his signature fight against Mexico's Julio Cesar Chavez, this time at the Thomas & Mack Center in Las Vegas. Camacho was roundly criticized for his lack of action, and the Mexican champion won a lopsided unanimous decision to retain the lightweight title.

    "Even though people say I beat him easily, it wasn't that way," Chavez told Mexico's ESPN-Radio Formula this week. "He was a very fast fighter, he faced everything and it was very hard for me."

    "He revolutionized boxing, Chavez said. "It's a shame he got mixed up in so many problems."

    After that loss, Camacho became the name opponent for other rising contenders, rather than the headliner fighting for his own glory.

    He lost a unanimous decision to another young Puerto Rican fighter, Trinidad, and was soundly defeated by De La Hoya. In 1997, Camacho ended Leonard's final comeback with a fifth-round knockout. It was Camacho's last big victory even though he boxed for another decade.

    The fighter's last title bout came in 1997 against welterweight champion Oscar De La Hoya, who won by unanimous decision. Camacho's last fight was his defeat by Saul Duran in May 2010. He had a career record of 79-6-3.

    Doctors pronounced Camacho dead on Saturday after he was removed from life support at his family's direction. He never regained consciousness after at least at least one gunman crept up to the car in a darkened parking lot and opened fire.

    No arrests and have been made, and authorities have not revealed many details beyond the facts that police found cocaine in the car and that the boxer and his friend, who was killed at the scene, had no idea the attack was coming. "Apparently, this was a surprise," said Alex Diaz, a police spokesman.

    Survivors include his mother; three sisters, Raquel, Estrella and Ester; a brother, Felix; and four sons, Hector Jr., Taylor, Christian and Justin.

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-11-24-Puerto%20Rico-Obit-Camacho/id-c495d20a313f493aad816bf8ae1c1d47

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    7 Apps You Don't Want to Miss

    Here for iOS

    Nokia released Here Maps for iOS this week. The application provides local transit, driving and walking directions. Places you enjoy visiting (or want to visit) in a city can be organized into Collections for easy access, and locations and directions to them can be shared with friends via SMS, email and social networks.

    Click here to view this gallery.

    [More from Mashable: 5 Shopping Apps To Help You Save Cash on Black Friday and Beyond]

    It can be tough to keep up with all the new apps released every week. But you're in luck -- we take care of that for you, creating a roundup each weekend of our favorite new and updated apps.

    This week, a mapping application brought public transit maps to the iPhone, and a popular location-sharing app finally made its way to Android.

    [More from Mashable: Facebook Tests Photo Sync For iOS [VIDEO]]

    We found an app that will help you make new friends while you're traveling for business, and an iOS app to help you decide what to cook for dinner when you're back home.

    Check out the gallery, above, for a look at this week's app highlights.

    If you're still looking for more, check out our previous Apps You Don't Want To Miss. Think we left a great new app off the list? Let us know in the comments below.

    Photo courtesy iStockphoto, scanrail.

    This story originally published on Mashable here.

    Source: http://news.yahoo.com/7-apps-dont-want-miss-173024596.html

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    Bangladesh clothes workers die in factory fire

    DHAKA (Reuters) - A fire swept through a garment factory on the outskirts of Bangladesh's capital on Saturday, killing at least nine people and injuring more than 100, police and witnesses said.

    The fire at the nine-story factory in the Ashulia industrial belt started on the ground floor and quickly spread. Firefighters took nearly five hours to extinguish the flames.

    Most of the victims died as they jumped from the building to escape the flames, a police official said. The death toll could rise, witnesses said.

    The cause of the blaze was not immediately clear.

    Bangladesh has around 4,500 garment factories that make clothes for brands including Tesco, Wal-Mart, JC Penney, H&M, Marks & Spencer, Kohl's and Carrefour.

    Readymade garments make up 80 percent of the country's $24 billion annual exports.

    (Reporting by Ruma Paul; Editing by Jon Hemming)

    Source: http://news.yahoo.com/bangladesh-clothes-workers-die-factory-fire-201016099.html

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    Saturday, November 24, 2012

    Bizarre Perpetual Sleepiness Explained

    A new treatment may help people with a bizarre medical condition that makes them perpetually sleepy.

    The findings, detailed Nov. 21 in the journal Science Translational Medicine, may provide relief for the people who sleep constantly and feel exhausted despite caffeine, other stimulants, and several alarm clocks.

    People with hypersomnia need to sleep about 70 hours a week and have trouble rousing from sleep. When they are awake, they usually feel as if they've pulled an all-nighter, and describe it as walking around in a fog. Most people come to a diagnosis after conditions like depression, sleep apnea or thyroid problems have been ruled out, said study co-author David Rye, a sleep researcher at Emory University.

    "You look for the typical causes, and then once you rule all those out, you're left with people who still sleep 12, 13, 14, 15 hours," Rye told LiveScience.

    For obvious reasons, intense sleepiness can put a crimp in patients' work and social lives. While no one knows exactly how many people have this condition, Rye estimates that roughly 1 in 800 people might be afflicted. Doctors often prescribe patients stimulants such as Ritalin or Adderall, but they don't usually work. [5 Things You Didn't Know About Sleep]

    So Rye's team wondered whether brain chemicals could cause hypersomnia. Because spinal fluid provides a snapshot of the chemicals floating around the brain, the team took spinal taps from 32 patients with the disease and 16 healthy subjects.

    When they put the spinal fluid in a dish with human cells, nothing happened.

    So the researchers added a chemical called gamma-aminobutyric acid (GABA), which helps the body shut down. The spinal fluid of the ultra-sleepy amplified the effects of GABA, making it bind much more often to the human cells. (Past research showed a link between GABA and sleep paralysis, or the phenomenon in which one wakes up while his or her muscles are still frozen.)

    The sleepy patients were producing a brain chemical that kept them half-sedated all of the time, Rye said.

    In a petri dish, adding a drug called flumenazil, which revives patients who have overdosed on sedatives such as Valium, reversed the effects of the sleepy peoples' spinal fluid.

    They then tested flumenazil in the sleepy patients. Before taking the drug, hypersomniacs performed as well as the extremely sleep-deprived or slightly inebriated on a test of alertness.

    "They're walking around essentially legally drunk all day," he said.

    Afterwards, the sleepy cohort performed almost as well as healthy individuals.

    The findings suggest that the drug could be an effective treatment for those with hypersomnia, but a follow-up study needs to prove that they actually sleep less at night, he said.

    Currently, the drug is only used to treat drug overdoses or to awaken patients unconscious from anesthesia, so the amount of the drug currently produced could only treat a handful of patients. Production would need to increase before it could be widely used, he said.

    Follow LiveScience on Twitter @livescience. We're also on Facebook?& Google+.?

    Copyright 2012 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

    Source: http://news.yahoo.com/bizarre-perpetual-sleepiness-explained-151531812.html

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